Since the city straddles the Reuss where it drains the lake, it has a number of bridges. The most famous is the Chapel Bridge (Kapellbrücke), a 204 m (669 ft) long wooden covered bridge originally built in 1333, the oldest covered bridge in Europe, although much of it had to be replaced after a fire on 18 August 1993, allegedly caused by a discarded cigarette. Partway across, the bridge runs by the octagonal Water Tower (Wasserturm), a fortification from the 13th century. Inside the bridge are a series of paintings from the 17th century depicting events from Lucerne's history. The Bridge with its Tower is the city's most famous landmark.

Lucerne city, lake and mountains view from the tower
Downriver, between the Kasernenplatz and the Mühlenplatz, the Spreuer Bridge (Spreuerbrücke or Mühlenbrücke, Mill Bridge) zigzags across the Reuss. Constructed in 1408, it features a series of medieval-style 17th century plague paintings by Kaspar Meglinger (de) titled Dance of Death (Totentanzzyklus). The bridge has a small chapel in the middle that was added in 1568.

Old Town Lucerne is mainly located just north of the Reuss, and still has several fine half-timber structures with painted fronts. Remnants of the old town walls exist on the hill above Lucerne, complete with eight tall watch towers. An additional gated tower sits at the base of the hill on the banks of the Reuss.

The twin needle towers of the Church of St. Leodegar, which was named after the city's patron saint, sit on a small hill just above the lake front. Originally built in 735, the present structure was erected in 1633 in the late Renaissance style. However, the towers are surviving remnants of an earlier structure. The interior is richly decorated. The church is popularly called the Hofkirche (in German) and is known locally as the Hofchile (in Swiss-German).

Bertel Thorvaldsen's famous carving of a dying lion (the Lion Monument, or Löwendenkmal) is found in a small park just off the Löwenplatz. The carving commemorates the hundreds of Swiss Guards who were massacred in 1792 during the French Revolution when an armed mob stormed the Tuileries Palace in Paris.

The Swiss Museum of Transport is a large and comprehensive museum exhibiting all forms of transport, including locomotives, automobiles, ships, and aircraft. It is to be found beside the lake in the northern-eastern section of the city.

The Culture and Convention Center (KKL) beside the lake in the center of the city was designed by Jean Nouvel. The center has one of the world's leading concert halls, with acoustics by Russell Johnson.

The Richard Wagner Museum is found on the lake at Tribschen and is dedicated to the composer Richard Wagner.[41] Wagner lived in Lucerne from 1866 to 1872 and his former villa now hosts the museum dedicated to him.